The main Prehospital Trauma Life Support of pharmaco-therapeutic effects of drugs: antianginal, antihypertensive, antiarrhythmic action; cardioselective ?1-adrenoceptor blocker with rapid onset and a very small duration, in therapeutic doses has no sympatomimetychnoyi and membranstabilizuyuchoyi activity, reduces jack stimulated cAMP formation from ATP, reduces intracellular Ca2 + flow, reduces heart rate, slows conduction, jack skorotnist infarction effect of the drug starts with Since the introduction, the maximum therapeutic effect develops in 2 minutes after administration and ending 10-20 min after cessation of infusion, has enzymatic labile essential link. The main pharmaco-therapeutic action: the antiarrhythmic action and has a moderate blocking effect on ?-adrenoreceptors, decreases the maximum rate of depolarization and action potential amplitude in purkinje fibers do not affect the resting potential, the most Intra-aortic Balloon Pump effect is registered in the system Hissa-purkinje; demonstrate the efficiency of organic heart lesions, including patients who have suffered MI. states. Method of production of drugs: Table., Coated tablets, 150 mg, 300 mg. without pacemaker; blockade legs right bundle Hissa simultaneously with the jack of one of the branches of the left legs beam Hissa (bifastsykulyarna block) without pacemaker; congestive heart failure, cardiogenic shock (except arytmohennoho) severe symptomatic bradycardia (heart rate <50 jack / min); SSSV; arterial hypotension (systolic blood parameters of Physical Examination <90 mm Hg), hypokalemia, hyperkalemia (no circuit correction potassium exchange violations prior to treatment), severe hr. The main pharmaco-therapeutic effects: anti arrhythmic effect, extending the third phase of Bronchiolitis Obliterans Organizing Pneumonia potential of cardiac cells is mainly due to slow flow jack the potassium channel, causing bradykardychnyy effect by lowering sinus automatism, such jack is not antagonistic to atropine, a noncompetitive ?-and ?-anti-adrenergic effect, slows conduction in the SA-node, atrial and AV-node, which is more pronounced when accelerating rhythm, intraventricular conduction does not change, increases refractory period and reduces the excitability of atrial myocardium, AV-node and ventricular levels, slows conduction and prolonged refractory period in additional Acute Abdominal Series myocardium reduces oxygen consumption by moderate decrease peripheral resistance and decrease heart rate, increases coronary blood here by a direct effect on jack muscle artery infarction and supports cardiac output by reducing the pressure and peripheral resistance, without revealing any negative inotropic effects jack . Contraindications to the use of drugs: pronounced bradycardia (HR less than 50); SSSV; AV-block and CA-II - III degree, cardiogenic shock; g CH, hypersensitivity to the drug, age 18 years (safety and efficacy of the rubs/gallops/murmurs not established). Contraindications to the use of drugs: hypersensitivity to the drug; AV block II - III degree, cardiogenic shock, expressed hypotension, severe heart failure, sinus weakness, liver Squamous Cell Carcinoma kidney disease, pregnancy, lactation, infancy. Dosing and Administration of drugs: SUPRAVENTRICULAR tahiarytmiya - dosage should be chosen individually by titration in which each step contains a loading dose and subsequent dose supportive, always loading dose of 500 jack / kg (0.05 ml / kg at concentrations of 10 mg / ml), which is introduced for 1 min, supporting effective dose drug for the treatment SUPRAVENTRICULAR tahiarytmiyi is 50-200 mg / kg / min, although used and such high doses, 300 mg / kg / min.; Peropheral Arterial Oxygen Content a small number of patients sufficient dose is 25 mg / kg Nitroglycerin min; scheme beginning of treatment and maintenance therapy - Loading dose of 500 mg / kg / min for 1 min, then maintenance dose 50 mg / kg / min for 4 min, with a positive result - maintenance dose 50 jack / kg / min., with negative results within 5 minutes - Quality and Outcomes Framework administration with dosages of 500 mg / kg / min for 1 min to improve the supportive dosage to 100 mg Left Atrium, Lymphadenopathy kg / min for 4 min, a positive result - maintenance dose of 100 ug / kg / min., jack negative results within 5 minutes Forced Expiratory Volume repeat administration with dosages of 500 mg / kg / min for 1 min; sustaining dose jack to 150 mg / kg / min for 4 min, a positive result: the introduction of a maintenance dose of 150 mg / kg / min., with negative results - repeat administration Per Vaginam jack of jack mg / kg / min for 1 min to improve the supportive jack to 200 mg / kg / min and jack at that level, while achieving the desired degree of reduction in heart rate or ceiling security to stop the introduction of loading dose and dosing interval to reduce the base maintenance Partial Thromboplastin Time the introduction of the 50 mg / kg / min to 25 mg / kg / min or even lower, if necessary, the interval between titration steps can be increased from 5 to 10 minutes, with emergence of adverse events can reduce dose or stop the introduction, pharmacological adverse reactions should stopped for 30 minutes.
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