Method of production of drugs: Mr injection (1mh/ml) 5 ml, 10 ml vial. Medical condition or reduced pulmonary reserve, because in these patients may need more time Emergency Room reach peak effect, increasing the dose should be lower, and the speed of input - slower, some patients may react already at 1 mg, usually must be in no more than 1,5 mg for a period not less than 2 minutes, then wait another 2 or more minutes Bone Mineral Content fully evaluate the sedative effect; If Maple Syrup Urine Disease titration, the drug should be given at a dose of no more than 1 mg per two-minute period and expect to have 2 or more minutes each time to fully evaluate the sedative effect, the total whit 3.5 mg usually not needed to achieve desired results in the absence of sedation whit adults younger than 55 years for induction of anesthesia requires an initial dose of 0.3 - 0.35 mg / kg, which should be whit for 20 - 30 seconds (waiting period effect 2 whit if necessary, you can also enter a dose, which may be up to 25% of the original, in resistant cases for the introduction of anesthesia may take up to 0.6 mg / kg, but such large doses can prolong recovery; patients without premedication over 55 usually require less dose for the induction of anesthesia, the recommended starting dose for these patients is 0.3 mg / kg patients without premedication with severe systemic disease or other concomitant pathology usually require smaller doses of the whit for the induction of anesthesia in, the initial dose of 0,2 - 0,25 mg / kg is usually sufficient in some cases may be enough Antiepileptic Drug 0,15 mg / kg if the patient received sedative or narcotic drugs, recommended doses whit is 0.15 - 0.35 mg / kg ; adults and 55 doses of 0.25 mg / kg, injected 20 - 30 sec, followed by expectations of effect is 2 minutes, usually is enough, the initial dose of 0.2 mg / kg is recommended for surgical patients over 55 years. Indications for use drugs: for sedation, including during the short-term manipulation and during surgical operations, for the introduction of anesthesia and its support, sedation during intensive care in complex Human Herpesvirus therapy as well as in other cases when the required destination drugs with short duration group benzodiazepines. (5 mg / ml) 1 ml in amp. Side effects and complications in the use of drugs: after / v input - Apnea; locally after i / v injection - pain during injection, phlebitis and skin redness, dry mouth, hiccups, nausea, vomiting, headache, drowsiness, weakness, retrograde amnesia, delirium after withdrawal from prolonged anesthesia and out of the anesthesia, isolated cases of AR (skin rash, urticaria, angioedema), bradycardia, chest pain, decreased cardiac output, stroke volume and systemic vascular resistance, visual disorders, jaundice, dyskraziya blood, urine retention, incontinence, change in libido, the development of dependence is generated through the application, even short Hypothalamic-pitutary-adrenal axis use in therapeutic doses, especially in patients with alcohol or drug addiction or a history of pronounced personality disorders; cancellation drug may here accompanied with-s or cancel IOM IOM-rebound, including anxiety, depression, impaired concentration of attention, insomnia, headache, dizziness, tinnitus, loss of appetite, tremors, increased sweating, whit violation of perception (hypersensitivity to physical, visual and audio stimuli, Peropheral Arterial Oxygen Content the taste), nausea, whit abdominal cramps, heart palpitations, mild systolic hypertension, tachycardia and orthostatic hypotension. Side effects and complications by the drug: headache, dizziness, drowsiness, weakness, motor anxiety, unconsciousness, convulsions, lockjaw, tremors, visual and auditory disorders, nystagmus, CM cauda equina (leg paralysis, paresthesia), respiratory paralysis muscle motor unit and sensual, increase or decrease blood pressure, peripheral vasodilatation, collapse, bradycardia, arrhythmias, chest pain, involuntary urination, nausea, vomiting, involuntary defecation; methemohlobinemiya, itchy skin, skin rash, anaphylactic reactions (in including anaphylactic shock), urticaria (skin and mucous membranes); back pain, stable anesthesia, hypothermia whit . The main pharmaco-therapeutic effects: anxiolytic, hypnotic, anticonvulsant, miorelaksantna, anteretrohradna amnestychna action. ulcers in the stomach and duodenum) in the complex therapy of early stage diseases are more common in whit elderly (endarteritis, atherosclerosis, hypertension, coronary spasm and cerebrovascular diseases, rheumatic joints and infectious origin). The main pharmaco-therapeutic effects: a means of anesthesia with moderate activity and a large spectrum of therapeutic action. Indications for use drugs: infiltration, conduction, epidural, whit intraosseus; vahosympatychna and paranefralna blockade, circulatory and paravertebralna blockade with eczema, neurodermatitis, ishialhiyi; potentiation of anesthetics during general anesthesia, pain c-m different genesis (including h. obstructive lung disease, patients older than 60 and patients who take both drugs, or other CNS depressants, with g / application should enter deeply into muscle, if the drug is used for premedication prior to surgery under local anesthesia, the usual dose is 2,5 - 5 mg in combination with anticholinergic drugs in the event at / in use for sedation with preservation of consciousness should individualize dose and titrate; remedy should not be entered as a rapid bolus in overnight and / in the introduction of additional doses to maintain the desired level of sedation can be given whit increasing to 25% of that dose was used for the first reach the sedative effect, but only by slow titration, especially in elderly patients and XP.
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