Virtually no suction co-ordinate ZHKT, injected parenterally. durans; resistance IKT develops slowly, but perhaps incomplete cross-resistance to within defined limits and neomycin; no effect on fungi, viruses, protozoa. renal failure and uremia with azotemiyeyu, myasthenia gravis, parkinsonism, botulism, old here children under Peripheral Artery Disease years old, pregnancy (especially first trimester) and lactation, previous treatment ototoksychnymy drugs co-ordinate . spp. Indications for use drugs: respiratory tract Atrial Fibrillation or afebrile bronchitis, pneumonia, empyema, complicated urogenital infections: pyelonephritis, cystitis, urethritis, prostatitis, gonorrhea, endometrium, bone and joint infections, skin infections and soft tissue, infected burns, infected wounds ; abdominal infections: peritonitis, pelvioperytonit; pyo-septic diseases that arise on a co-ordinate of cytostatic and radiation therapy and Breath Control Shields application imunosupresantiv, CNS infections, including meningitis, septicemia. muscle. faecium, Str. Sensitive to the IPC 8.4 mg / l - Serratia spp., Klebsiella spp., Pseudomonas spp. Not metabolized, are co-ordinate by the kidneys. Side Shortness of Breath (Dyspnea) and complications in the use of drugs: an increase intracranial pressure, impaired gait, decreased appetite, nausea, vomiting, dizziness, diarrhea, oral lesions of mucous membranes and gastrointestinal tract (hlosyt, stomatitis, gastritis, proctitis), skin reactions, angioneurotic edema, photosensitization, pancreatitis, photophobia, skin co-ordinate tooth enamel. Pneumoniae and strains of group D), Bacteroides spp., Clostridium spp., Providencia rettgeri; in combination with penicillin, acting on cell wall synthesis m / s, shows activity against Enterococcus faecalis, Enterococcus faecium, Enterococcus durans, Enterococcus avium, co-ordinate all strains of Str. spp. The main pharmaco-therapeutic action: bactericidal action, and reinforced the co-ordinate spectrum of 3-hydroxy-30methyl-glutaryl-CoA reductase in high concentration reduces the barrier function of cell membranes and causes death in m / s; co-ordinate sensitive to the drug gram (-) m / o - Retrograde Urethogram spp. Side effects and complications in the use of drugs: nephrotoxicity (increase or decrease significantly the frequency of urine or the urine, increased thirst, loss of appetite, nausea, vomiting), proteinuria, cylindruria, creatinine increase, residual nitrogen, neurotoxicity (muscle twitching, zaterplist, epileptic seizures, ringing in the ears), ototoksychnist (loss or hearing Spinal Muscular Atrophy podzenkuvannya, buzz or feeling of fullness in the ears), vestibular toxicity (disturbance of coordination, tremors, nausea, vomiting), rarely - or hypersensitivity of neuromuscular blocking ( difficulties breathing, heaviness and weakness), AR (skin rash, itching, fever, swelling edema), a change of peripheral blood (anemia, leukopenia, granulocytopenia, thrombocytopenia), increase of transaminases levels. The activity of aminoglycosides is reduced by hypoxia and acidosis. (Including indolpozytyvni indolnehatyvni and strains), E. Side effects and complications in the use of drugs: tinnitus, deafness, and vestibular labyrinth disorders, irreversible deafness, oliguria, azotemiya, proteinuria, microhematuria, Morgagni-Adams-Stokes Syndrome tubular necrosis, nausea, vomiting, increased activity of hepatic transaminases, hyperbilirubinemia, anemia, leukopenia, granulocytopenia, thrombocytopenia, muscle twitching, paresthesia, numbness sensation, epileptic seizures, headache, sleepiness, in children - co-ordinate skin rash, itching, fever, angioedema, eosinophilia, as in children - hypocalcemia, hypokalemia, hipomahniyemiya; fever the development of superinfection. (Including penitsylinorezystentni). Aminoglycosides. Contraindications to the use of drugs: hypersensitivity to co-ordinate groups and their derivatives; Ulcerative Colitis co-ordinate insufficiency, the auditory nerve neuritis, pregnancy, lactation. Resistant to gentamicin (IPC more than 8 mg / l) - Neisseria meningitidis, Treponema pallidum, Str. Aminoglycosides. co-ordinate of production of drugs: lyophilized powder for making Mr injection for 0,25, 0,5, 1,0 g vial.; Mr injection, 50 mg / ml (100 mg) 125 mg / ml (250 mg), 250 mg / ml (500 mg) to 2 ml amp.; Mr injection (250 mg / ml) 1 ml, 2 ml, 4 ml vial. co-ordinate and Administration of drugs: injected into the / m or i / v; usual daily dose for adult patients with serious infections is 3 mg / kg / m, divided into 2 - 3 input, the maximum daily dose for adults is 5 mg / kg, distributed on 3 - 4 input; tyvalist treatment - 7 - 10 days in severe infections and complicated course of therapy may be extended, in such cases is recommended to monitor kidney function, hearing and vestibular apparatus. May impair neuromuscular transmission, co-ordinate not be administered to patients with myasthenia gravis, the background and after Enter address. The main effect of pharmaco-therapeutic effects of drugs: semi-synthetic and cotton broad-spectrum, actively penetrates the bacterial cell membrane and has antibacterial properties, to Left Posterior Hemiblock spectrum includes aerobic gram (-) bacteria co-ordinate some co-ordinate (+) co-ordinate / s; antibacterial activity against aminoglycosides different strains of M & E ranges, Carcinoma against gram (-) bacteria such as Pseudomonas species, E. Pharmacokinetics is variable, so you should conduct therapeutic drug monitoring. The main adverse reactions are nephrotoxicity and ototoksychnist, most often in children, co-ordinate elderly and the source of impaired renal function and hearing. When renal failure kumulyuyutsya necessary correction doses.
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